SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression

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SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression.

During asymmetric cell division, cell polarity and cell cycle progression are tightly coordinated, yet mechanisms controlling both these events are poorly understood. Here we show that the Bora homologue SPAT-1 regulates both PAR polarity and cell cycle progression in C. elegans embryos. We find that, similarly to mammalian cells, SPAT-1 acts with PLK-1 and not with the mitotic kinase Aurora A ...

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ژورنال

عنوان ژورنال: Development

سال: 2010

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.055293